January 1, 2013
Role of Stem/Progenitor Cells in Reparative Disorders

Thavaneetharajah Prethebaan, Dario R Lemos, Benjamin Paylor, Regan-Heng Zhang, Fabio M Rossi

LINK: http://www.ncbi.nlm.nih.gov/pubmed/23270300

ABSTRACT: Adult stem cells are activated to proliferate and differentiate during normal tissue homeostasis as well as in disease states and injury. This activation is a vital component in the restoration of function to damaged tissue via either complete or partial regeneration. When regeneration does not fully occur, reparative processes involving an overproduction of stromal components ensure the continuity of tissue at the expense of its normal structure and function, resulting in a “reparative disorder”. Adult stem cells from multiple organs have been identified as being involved in this process and their role in tissue repair is being investigated. Evidence for the participation of mesenchymal stromal cells (MSCs) in the tissue repair process across multiple tissues is overwhelming and their role in reparative disorders is clearly demonstrated, as is the involvement of a number of specific signaling pathways. Transforming growth factor beta, bone morphogenic protein and Wnt pathways interact to form a complex signaling network that is critical in regulating the fate choices of both stromal and tissue-specific resident stem cells (TSCs), determining whether functional regeneration or the formation of scar tissue follows an injury. A growing understanding of both TSCs, MSCs and the complex cascade of signals regulating both cell populations have, therefore, emerged as potential therapeutic targets to treat reparative disorders. This review focuses on recent advances on the role of these cells in skeletal muscle, heart and lung tissues.

December 12, 2012
Science.ca Profiles of Drs. Jim Till and Ernest McCulloch

A scientific story that far too Canadian are not familiar with is growing in prominence, everyone can expect to hear a lot more in coming years about this incredible biomedical contribution our country has made.

It’s a little known fact is that one of the first proofs of existence for a type of cell called a “stem cell” was made here in Canada by two researchers, Drs. Jim Till and Ernest McCulloch, at the University of Toronto in the 1960s. Wow! But everyone loves stem cells and is so curious about who discovered them, how does everyone not know this?

Me and Mike’s animation studio, InfoShots, is currently producing a set of animated videos explaining stem cell science, titled “StemCellShorts”. Our first video (“What is a stem cell?” - Narrated by Dr. Jim Till) is just finishing post-production and to prepare for it’s launch, I’ve done a little writing!

Science.ca is Canada’s most visited science website, and features several profiles of prominent Canadian scientists. I am hoping to complete a bio for each scientist featured in our animated series, and the first profiles of Drs Till and McCulloch are now live on the site. A lot of research for these pieces was obtained from the recently published great read “Dream and Due Dilligence - Till and McCulloch’s Stem Cell Discovery and Legacy” and personal correspondence with Dr. Till, who was incredibly supportive and helpful in this process.

We are all tremendously excited for the launch of the animations in the coming months, but for now, a text-based biography will have to satiate your curiosity!

LINK: Dr. James Till - http://www.science.ca/scientists/scientistprofile.php?pID=467

LINK: Dr. Ernest McCulloch - http://www.science.ca/scientists/scientistprofile.php?pID=468

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December 11, 2012
The Science of Poetry / The Poetry of Science

This coming Friday at 6:30pm I will be taking part in a really cool free event called The Poetry of Science that will be taking place at Gallery 1965 (1965 Main Street).

You should come! (Facebook event link - http://tiny.cc/3d06ow)

The first of it’s kind here in Vancouver, The Poetry of Science explores what wonderful things happen when five scientists get together with five poets to create new poetic works. I was paired up with the incredible local poet Leanne Dunic, who I was lucky enough to work with over the past few weeks to develop both my own, and her poem. Leanne was able to come to my lab to observe some of my experiments, and her support was vital in the process of me writing my poem. My poem is a reflection about this unique experience, and explores the nature of observation as well as the parallels between the purpose and process of poetry/science.

The event has been getting some good traction in a few different news outlets, with my fellow participant and Banff Science Communication 2011 alumni friend Lynne Quarmby getting a great write up in the SFU News, and the event being put on SCOUT Magazine’s “11 Things That You Should Absolutely Do Between Now & Next Week”.

The Poetry of Science was masterminded by the wonderful Aileen Penner (also a 2012 alum of the Banff Sci. Comm. program) and also features a welcoming address by Vancouver’s poet laureate, Evelyn Lau, a cash bar (always fun!) and DJ Koalafy! 

If you are free this evening (Friday, December 14th from 6:30-9:30pm!), come join!

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November 22, 2012
F1000 - Evaluation of Dularoy et al. (2012) - Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury.

An evaluation I wrote of a recent Nature Medicine paper describing a functional fibrotic sub-classification within our lab’s PDGFRa+ Sca1+ muscle-resident progenitors (described by our group and another in Nature Cell Bio in 2010). An interesting paper (I love genetic ablation experiments!).

LINK: http://f1000.com/prime/717959620

October 15, 2012
Selected to present in UBC event: “The President’s Blue and Gold Revue”

I was recently selected to present about my animation work and research in an upcoming celebration of excellence at UBC, which is great! The event, “The President’s Blue and Gold Revue” being held on Thursday, October 18th at the Vancouver Convention Centre, and is an annual gala hosted for the numerous (and generous) donors for UBC. It is meant to showcase top student/staff talent at the university.

LINK: http://startanevolution.ubc.ca/blue-and-gold-revue/stemcell/

My presentation is as follows:

“StemCellShorts is the latest animation production from InfoShots, a Vancouver-based animation studio run by UBC student Ben Paylor, a PhD candidate in Experimental Medicine.

The project, funded by a public outreach grant from the Stem Cell Network, pairs Ben’s background in stem cell research and passion for science communication with an award-winning local animator, David Murawsky, and a Gemini and Emmy nominated composer, James Wallace. This production is a series of animated shorts, each featuring a prominent Canadian stem cell scientist exploring the exciting field of stem cell research in an engaging and educational manner.

The first short of the series features the world famous Canadian scientist Dr. Jim Till, who alongside the recently passed Dr. Ernest “Bun” McCulloch, made Canadian medical history when they first described the presence of stem cells in 1964. In this short film, Dr. Till explores the most basic question of “What is a stem cell?” “

Excited to be involved!

October 15, 2012
GeneScreenBC - 3rd Place and People’s Choice Award for Deflating the Genomic Bubble!

For the 3rd year in a row, Marcus, Lauren and I have put together a short film for GeneScreenBC, a genetics film festival hosted here in Vancouver. This year was certainly the most disappointing year in terms of the quantity of entries in the competition (15-20 in previous years, and 3 this year), but it was still fun to make the piece. Our film can be viewed at the following link (if you haven’t seen it already!) - http://www.youtube.com/watch?v=Lv29LXb2cWQ&feature=youtu.be

Challenging yourself to communicate in new mediums is an incredible learning experience, and one that I would advocate for anyone trying to develop their communication skills. Given some frustrations with the judging process in previous years, we decided to limit the amount of time/effort we invested in this piece and (inspired by numerous 24/48 hour film festivals) we wrote/filmed/edited the entire film in about five days! The original goal was to aim for the People’s Choice Award, and with the support of our viewing public/friends/family we were able to win this award (again!).

Filmmaking is definitely a difficult process and its very difficult to maintain perspective on the big picture (what are we trying to communicate? what details are necessary/disposable? etc.) but the challenges are what make it so fun. Lauren and Marcus, two of my oldest and dearest friends, were an integral part of the fun involved in this, and it’s great to work on creative projects such as this with your best pals!

October 3, 2012
Action Canada - Northern Policy Adventures in Haida Gwaii

*I also made an album of ALL my photos from Haida Gwaii if you want to take a look!* 

“Grandfather eventunally told Loon to go to the longhouse where the loon would find a box. Loon opened that box and found another box, and when Loon opened that box, he found another box. Inside it, he found a black stone and a white stone. As grandfather instructed, Loon blew as hard as he could on the black stone and threw it as far as he could. This became North America. Then he took the white stone, blew on it softly, and tossed it gently, and this became the land that we are on today: Haida Gwaii. Just as loon was able to plead to grandfather, the people are today able to care for loon.” - Story of the Creation of North America and Haida Gwaii by Gwaaganad (Diane Brown), Haida Storyteller and Medicine Woman

Sunrise in Skidegate

In an effort to improve the Action Canada fellow’s understanding of Canada, each year, the program takes a trip to a northern community. Previous years trips have visited locations such as Northern Labrador, Yellowknife, and even Alert. This year, our destination was the remote archipelago of Haida Gwaii - The Islands of the People (formally known as the Queen Charlotte Islands). I think I can speak for all of the fellows in saying that this Northern Conference was highly anticipated and, hearing from previous fellows, was expected to be one of the most incredible experiences of the fellowship year.

Having just returned from this unique and remarkable part of Canada, I can assert that all these expectations were exceeded. All of us who travelled to this beautiful isolated destination off the coast of Northern British Columbia left with a much broader and deeper understanding of both it’s culture and history

View from the Haida Heritage Centre

The Northern Policy Conference reassigns fellows into new groups (I was excited to work with a new group, but sad to leave my dearest Team Awesomes). Three policy teams were formed to meet and work with local leaders involved with three different issues: environmental governance (my group!), economic development, or self governance. An expert policy report on each topic was prepared prior to the conference as an introduction to the topic (one of which being prepared by Tony Penikett, former Premier of the Yukon Territories, who was with us in an advisory capacity for most of our time there. Great man!). Off to Haida Gwaii we go!

Upon arriving (flying into Sandspit - and ferrying to Skidegate), we were treated to an introductory dinner at the home of a woman named Roberta. She made absolutely incredible food for us (the vast majority of which had been picked/harvested/caught by her and her family). We were given a great Haida Gwaii 101 lecture by 04/05 Action Canada fellow Severn Suzuki-Cullis (if you haven’t seen this video already, you should!), who provided us with an excellent perspective of the islands and their people (or the other way around).

The first half of our time on Haida Gwaii was spent meeting with numerous individuals involved with our assigned policy topic, which, for our group, included: the Parks Canada superintendent of the supernatural Gwaii Haanas national park, Gwaaganad (who told us the story included above), a nature guide and interpreter, a couple highly involved in the development of Haida Gwaii’s environmental politics (one being a cartographer and the other a municipal councillor, amongst other things), a forestry consultant and, finally, a woman working on developing a proposed Marine Conservation Area around the islands. Everyone was very open and honest and I was amazed at how much we were able to learn about environmental governance in such a short amount of time. The aforementioned couple invited us into their home for dinner where, after 2 days of intense meetings and discussions, we spent an evening reflecting on our discussions and planning for the next step - a public dialog to share what we had learnt with interested locals and community members.

Vassiliki (Vass) Bednar speaking during our public dialog

The dialogues were a resounding success, somewhat surprising to me given the depth of the topics we had been working on and the limited time for preparation. Having gone through such a whirlwind process of both educating ourselves on the issues and then reflecting our learning back to the public was incredible, and allowed us with an open space in which to practice our public speaking and leadership skills. I’d love to dig into detail about everything we learnt about, but I don’t think a short blog post could do it justice.

A piece of art by John Broadhead in response to the proposal for the Enbridge pipeline

Although a core focus of this conference was the public dialog, there was plenty of time allowed for exploring and awesome trips on the island. Some highlights:

  • Meeting Guujaaw, the President of the Council of the Haida Nation, who has been an instrumental player in the politics and activism that have made Haida Gwaii famous to the world (e.g. being involved in the Lyell Island conflict in the 80s). Having just returned from testifying at the Enbridge hearings in Edmonton (one cause, for which there is unilateral support on the islands, is opposition of the pipeline), he spoke with us about his role in provincial and federal politics, and his perspective on the future of Haida Gwaii.
  • Taking the Loo-plex, a full-scale fibreglass model of Bill Reid’s famous Loo Taas canoe
2012/13 Fellow and Advisors out on the Looplex with the beautiful Haida Heritage Centre in the background
  • The FOOD! Someone told me that the food on HG is called “Millionaire Food” and they were spot on. The quantity and quality of all the amazing seafood we ate there was incredible. A highlight certainly being the Roe on Kelp (dried or cooked!) that was waiting for us around every corner
  • Attending Haida Cultural Night where we got to participate in some traditional song and dance. Although it was one of the few times during the visit that I felt like an “observer”, it was still run in a participatory manner that was fun, open and memorable
  • Visiting North Beach, a site which is central in many of the Haida’s legends about the birth of man. You can instantly understand why when you see the long, serene, untouched beach stretching as far as you can see.

Justice Malcolm Rowe and the rest of the boys doing a warrior dance in Massett

This conference, our third of the year, very much deepened my connection with all of my fellow Fellows, and further reinforced our shared goals and values. The group that has been chosen for this program is truely incredible, and I feel very honored and thankful to be a part of it. I’m back in Vancouver now, struggling to get my mind back into that of a biomedical PhD student, while lingering thoughts and feelings of the island remain.

October 1, 2012
Guest Post - Action Canada - Introducing Ben Paylor: All Around Awesome

By Annie Sabourin

Ben provided an excellent introduction to the Team Awesomes, but his post was lacking in one regard: it didn’t include himself! A description of the team is not complete without a portrait of him, in the context of Action Canada.

Ben Paylor - ”The Organizer/Conference Organizer and Budget Lead”

At first glance, Big Ben could fit the shy introvert stereotype: he is a scientist, carries his camera everywhere, scribbles in a black Moleskin notebook, and has this mean, cold look on his Action Canada bio picture. Fortunately for us, this multi-talented Xavier Dolan look-alike is of the creative and demonstrative type, as illustrated by his award-wining movie making, bare-foot public speaking, spontaneous piano-playing and generous hugging.

I can’t imagine a better logistics coordinator: it is my experience that if you want something to happen, all you need is to mention it to him and minivans will be rented, meetings will be scheduled and crowds will follow. He is infectiously happy and always ready to get the party started, stepping up as DJ, liquor store locator, or super clapper (yes, ask him to show you his hidden superpower). The man has been known to lose a few things… but never his cool. With his famous van, his painted toenails and bow-tie, he sure is a cooky original, but he’s a magical master at making everyone feel just as special. Proud to say I’m playing on his team.

September 27, 2012
Action Canada - An Introduction to Team Awesome

A core component of the Action Canada program is participation in a task force project, which focuses on a particular aspect of the years policy theme. This project involves the development of an in-depth report containing policy recommendations as well as the organization of a public dialog surrounding the topic. Looking at previous reports, there is no doubt of their impact on public policy issues (the 2010 report on Household Debt certainly coming to mind). Measuring impact can also be a somewhat nebulous thing to assess, with contributions such as advancing public discourse and/or getting fellows personally invested and involved in the topic at hand also being clear long lasting contributions.

The amount of time and discussion necessary to select a topic is arduous to say the least, and this is only the beginning. The topic must be defended to the fellowship program and it’s advisors by the end of the second conference, as well as researched and discussed vigorously (till you’re not sure what it even is about anymore) in order to develop a preliminary report before the 3rd conference. By the fall, the topic must be built into a public dialog featuring numerous experts discussing the topic, and finally written up into a bi-lingual report and delivered at a policy forum in Ottawa in the spring. To add to the challenge, the topic of the entire project is generally outside of Fellows areas of expertise and requires members to develop not only an expert perspective on select policy issue, but also a set of recommendations on how to advance these issues in Canada. 

This was the part of the Fellowship that I was certainly most at unease about, but I can happily say 5 months into my Action Canada fellowship that these doubts have subsided. These feelings of relative comfortability don’t arise from my own actions however, and can almost wholly be attributed to the awesome group I’ve been lucky enough to be thrust into. Introducing Task Force Team Two A.K.A. Team Awesome!

Upon first reading of my Task Force team assignment, I was amazed at the super group I had been thrown into. At our first conference in Quebec City, we spent a number of hours discussing who each of us was, our strengths/weaknesses, and passions/ambitions. I was blown away at the company I found myself in. On top of this stellar team, each group is gifted with an advisor to guide us throughout the year. You can read all of their bio’s on the AC Bio’s page (bio’s are also linked below) but who actually are they? I also include a mention of the “Role” we have decided to take within the group (I am the “Conference Organization and Budget Lead”)

Annie SabourinThe Mother/”Covener” - Annie truly is the mother of the group, with a finger to the pulse of each members level of engagement, productivity and involvement at all times. Incredibly available and present in any situation, Annie is gem and, more than anyone else in the group, our group wouldn’t be the same without her. A selfless free spirit, we’ve really connected and I’m glad she’s in my team! Annie is involved with the presidents office at the Universite de Montreal.

Felix Boudrelaut - The Manager/”Operations Lead” - Felix is the man. I’d liken his managerial style to that of a chess player, as he has the great strength of being able to anticipate what comes next and prepare for it. In our discussions and planning, he is continually able to steer and guide the ambition and energy of the group (it is overwhelming at times) towards the task at hand. He also has some great stories about when he was younger with a scooter and a Felix the Cat hat. Felix is a Senior Policy Advisor for Environment Canada.

James Haga - The Dreamer/”Communications Lead” - Right off the bat, James really blew me away with his big ideas. We would be following a somewhat certain and linear logical process, and James would continue to drop bombs of idealism from above, continually revisiting the broader topics connecting our tasks. His tendency and ability to ask the important questions - What are we actually doing? What do we want? How do we want to change the world? - allows him to simultaneous expand our perspective and narrow our focus towards the common underlying goals of the group. Go James Go! James is the Director of Advocacy for the organization Engineers Without Borders.

Cliff Van Der Lindin - The Analyst/”Lead Writer” - The butt of many a jokes in the group due to his obsession with data and regressions (sorry Cliff), I think it’s safe to say that Cliff constitutes a driving force in the analytic and academic capacity of the group. After our introductory session of the group, it was clear that Cliff possessed a tremendous ability to synthesize highly structured and complex thoughts. He uses wonderful words and I love to listen to him talk (you will too). Cliff is a PhD Candidate in Political Science at the University of Toronto and also does a lot of cool stuff - one of which is running Vote Compass

Samira Thomas - The Educating Traveller/”Research Lead” - I don’t think I know what everyone in the group exactly does all the time, but with Samira I pretty much have no idea. She certainly comes off as a jack-of-all-trades, a learner who is able to pick up the pieces in any situation and put them to use. Her weekly emails seem to come a dozen different countries per week, each one outlining another amazing project and pursuit. A multi-faceted and dynamic individual, Samira is also a driving force of enthusiasm in the group, a go-getter! Samira just graduated from MIT with a Masters of City Planning and does about a hundred other projects.

Rae HullThe Challenger/”Task Force 2 Advisor” - We are incredibly lucky to have been assigned Rae as our advisor, who has consistently pushed and tested our ideas at every step of the project. She has an excellent understanding of how audiences think, and we certainly wouldn’t be where we are now without her “kicking the tires” of our plans at each step. She also feels that we produce “decent” work. Rae currently consults on a number of projects and was formerly involved with the CBC and the 2010 Vancouver Olympics.

September 17, 2012
GeneScreenBC - Our film “Deflating the Genomic Bubble” - Please vote!

For the 3rd consecutive year, me and some friends have created a short-film for the GeneScreenBC competition, which aims to “excite and engage the public about the role of genetics and genomics in human health.”

Our piece, Deflating the Genomic Bubble, aims to look at the topic in a slightly different manner. Inspired by an article by the same name in the prestigious journal Science (sadly, it’s behind a pay-wall) as well as a recent novel by Tim Caulfield titled “The Cure For Everything”, the short-film aims to promote discussion about our expectations of genomics research. 10 years since the completion of the Human Genome Project and, with it, the birth of the field of genomics, despite incredible progress in the field scientifically there is a strong case to be made that near-term clinical benefits resulting from this research have yet to manifest, and in some instances may never.

LINK: http://www.youtube.com/watch?v=Lv29LXb2cWQ&feature=youtu.be

From my perspective as a stem cell researcher, there is much more awareness now from the research community about the danger inherent in the claims we make about our research. Taking a critical view of similar promises and expectations surrounding genomics research yields some interesting insights (the article is great!). I’ve thought for some time about different ways to take academic articles and translate them into more accessible forms, but this is the first time we’ve tried it with a short video. It’s definitely difficult to convey all the detail contained in the article (we had to cut a lot!), but this form of media is certainly a good way to provoke thought and discussion around the topic.

If you have a moment, please REGISTER and VOTE for our film at the following link (there is a $1000 prize for the “Peoples Choice Award” in this competition) - http://www.genescreenbc.com/2012-videos

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